Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 14 (Jul. 15, 1987), pp. 4781-4785 (5 pages) RepA, an initiation protein of R1 plasmid replication, was ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 15 (Jul. 22, 2003), pp. 8692-8697 (6 pages) The DnaA replication initiation protein has been shown to be ...

Figure 1: A meganuclease (I-SceI) serves as a negative feedback element in this synthetic quorum oscillator by targeting the activator plasmid. Because the synthetic oscillator circuit we constructed ...

Toxin-antitoxin (TA) systems are now known to negatively control plasmid replication. Toxin-antitoxin (TA) systems are now known to negatively control plasmid replication, according to Thomas Wood, ...

Plasmids, small circular DNA molecules found in bacteria, may contain antibiotic-resistance genes and have the ability to replicate independently. Bacteria can transfer these plasmids to one another, ...

Astrivax BV has raised €30 million (US$30.1 million) in a seed round to take forward the development of a novel vaccine technology that combines a plasmid vector with a replication-competent virus.

Adeno-associated virus (AAV) vectors play a pivotal role in gene therapy, delivering therapeutic genes with high precision and safety. However, a significant challenge in the biomanufacturing of these ...

Plasmid DNA lies at the heart of viral and mRNA vector production because it provides the coding sequences for gene-based advanced therapy medicinal products (ATMPs). Its manufacture is therefore ...